Applegate's Memoir Documents Personal Journey Through Health Crisis
Applegate releases memoir 'You with the Sad Eyes,' sharing her personal health journey account.
Event / Health
Christina Applegate Health Crisis
Actress Christina Applegate hospitalized in Los Angeles in late March 2026 amid ongoing battle with multiple sclerosis, which she was diagnosed with in August 2021. She has been hospitalized over 30 times since diagnosis and recently experienced a significant MS flare-up with severe mobility issues in January 2026.
2 reported locations
Daily activity
0 articles0 articles
2026-08-18 to 2026-11-15 · UTC publication dates
Coverage begins 18 Apr, 02:36 UTC
Follow the documented timeline or explore the related reporting.
What happened
Christina Applegate's 'MeSsy' podcast takes hiatus in late March 2026
The 'MeSsy' podcast, co-hosted by Christina Applegate and Jamie-Lynn Sigler, announced a short break in late March 2026. Both hosts were focusing on book tour commitments, with Sigler announcing on March 31 that the show would be on hiatus for a few weeks.
Christina Applegate reports hospitalization over 30 times since MS diagnosis
In March 2025, Applegate disclosed on her podcast that she has been hospitalized more than 30 times since her multiple sclerosis diagnosis in 2021. She indicated that extensive medical testing including multiple CT scans and radiation exposure have been part of her treatment regimen.
Christina Applegate hospitalized with kidney infection in August 2024
Christina Applegate was hospitalized for a kidney infection, spending seven days in the hospital before returning home. She disclosed this medical event on an episode of her podcast recorded while still hospitalized.
Christina Applegate diagnosed with multiple sclerosis in August 2021
Actress Christina Applegate publicly revealed her diagnosis with multiple sclerosis in August 2021. She initially experienced symptoms including numbness in her toes and feet while filming Netflix's Dead to Me, which prompted medical evaluation and diagnosis.
Christina Applegate releases memoir 'You with the Sad Eyes'
Actress Christina Applegate released her memoir titled 'You with the Sad Eyes' on March 6, 2026. The memoir became a New York Times number one audiobook bestseller, which Applegate recorded herself. In the memoir, she discusses her personal struggles and her experience living with multiple sclerosis.
Christina Applegate hospitalized in Los Angeles in late March 2026
Actress Christina Applegate was admitted to a Los Angeles hospital in late March 2026, according to sources with direct knowledge. The reason for her hospitalization remains unclear, and her representative declined to confirm whether the hospitalization was related to her multiple sclerosis diagnosis or other medical conditions.
Christina Applegate reports proneness to infections due to MS treatment
Christina Applegate disclosed that her multiple sclerosis treatment regimen makes her prone to infections because the infusions kill her B cells, which are responsible for producing antibodies. She indicated that she frequently requires emergency room visits due to infections.
Christina Applegate experiences MS flare-up with mobility issues in January 2026
In January 2026, Christina Applegate described experiencing a recent multiple sclerosis flare-up on her podcast, during which her mobility deteriorated significantly. She described transitioning from walking relatively well one day to falling over and stumbling the next day, expressing concerns that the disease is progressively taking her abilities.
Read the coverage
2 alternative perspectives
Applegate's 'MeSsy' podcast pauses as health challenges continue
Applegate's 'MeSsy' podcast paused in March 2026 amid ongoing MS health management.
Applegate Hospitalized in Los Angeles Amid Ongoing MS Health Challenges
Applegate hospitalized in March 2026, marking another episode in her ongoing MS health management since 2021 diagnosis.